六月出席每年一度的粉紅絲帶乳癌防治宣導慈善晚宴，透露婚前曾檢查出胸部有0.7公分的腫瘤，「等報告那2個星期，是我這輩子最漫長的」。後來報告出來．是良性腫瘤，而且最後腫瘤自行消失。Relevant post: Disappearing breast cancers
Does cancer disappear without having any treatment? Over 1,000 case studies document cancer sufferers who experienced spontaneous regression of their tumours. But tumours are varied, both in their genetics and their behavior. Also, tumours of the same type mutate in many different ways, which influence the rate of tumour growth, or the likelihood of spread of the tumor to different locations, or how responsive the tumors to treatment. Thus, genetic mutations are linked to spontaneous regression.
“Spontaneous regression” or “spontaneous remission.” refers to cancer and benign tumors “disappear” without any treatment. Spontaneous regression of cancer is defined as: “the partial or complete disappearance of a malignant tumor in the absence of all treatment, or in the presence of therapy which is considered inadequate to exert a significant influence on neoplastic disease.” (Reference: Spontaneous Regression of Cancer: Explanations and Predictions by Clifford Pukel, MD )
Some patients experience relentless disease progression. And some patients experience spontaneous regression of the tumors. In the late 1800s, William Coley observed that inducing a fever could result in tumour regression. Besides, William Coley developed a bacterial vaccine (“Coley’s vaccine”) which was successful in reducing tumours in many of his patients.
The question is: Does tumor regression have something to do with the immune system? Also, the researchers found that some skin tumours (malignant melanoma) show excessively high numbers of the body’s immune cells inside the tumour.
In another interesting case report, a patient with kidney cancer had a part of his tumour surgically removed, and the rest of his tumour resulted in the spontaneous regression. In this case, the researcher believes that the immune response following the surgery stops the growth of the rest of the tumour.
About 100 children are diagnosed with neuroblastoma every year in the UK, which is a type of rare childhood cancer. Studies found that tumours in children under 18 months can disappear with or without any treatment (type 1). But children older than 18 months need intensive treatment and have only a 40-50% survival rate (type 2).
The researches found that type 1 neuroblastomas have high numbers of a cell receptor (TrkA), which trigger tumour cells to kill themselves. In contrast, type 2 neuroblastomas have a higher number of a different receptor (TrKB), which makes the tumours get more aggressive.
Do breast cancer lumps disappear?Many women found a lump in their breast, don’t panic. Most lumps are not breast cancer, and some lumps will disappear without any treatment. In younger women, lumps are often related to menstrual periods and will go away by the end of the cycle. (Reference)
Tumours have been known to disappear spontaneously without having any targeted treatment. Breast tissue naturally has a bumpy texture. The proportion of breast cancer or breast tumors is actually quite high. Regular massage of the lymphatic acupoints on both sides of the armpit should be helpful for preventing breast cancer. Because blood circulation is decidedly helpful to trigger our self-healing system and accelerate body recovery.
Spontaneous regression may in some cases be a manifestation of this dynamic process and some cancers that undergo spontaneous regression might recur years later.
“Spontaneous regression of cancer is reported in virtually all types of human cancer[…] Mechanisms proposed for spontaneous regression of human cancer include: immune mediation, tumor inhibition by growth factors and/or cytokines, induction of differentiation, hormonal mediation, elimination of a carcinogen, tumor necrosis and/or angiogenesis inhibition, psychologic factors, apoptosis and epigenetic mechanisms […] Another example of this phenomenon can be seen with the so-called abscopal (or out-of-field) effects of radiation therapy, which causes the immune system to mount a systemic response to distant metastases.35 ” (Reference: Spontaneous regression of cancer: possible mechanisms by Section of Medical Oncology, Yale University School of Medicine, New Haven, CT 06520, USA.)
#spontaneous regression of cancer
#immune system activation (or reactivation)
Common warning signs of breast cancer:
Change in the size or shape of the breast
Dimpling or puckering of the skin
Nipple discharge: liquid leaking from your nipple
Pain in your breasts may be related to your menstrual period. However, if the pain persists after the period, please don’t ignore it.
- Pack GT. St. Peregrine, O.S.M.–the patron saint of cancer patients. CA Cancer J Clin. 1967;17(4):181-2.
- Jackson R. Saint Peregrine, O.S.M.–the patron saint of cancer patients. Can Med Assoc J. 1974; 111(8):824-7.
- Krone B, Kölmel KF, Grange JM. The biography of immune system and the control of cancer: from St Peregrine to contemporary vaccination strategies. BMC Cancer. 2014;14:595. doi: 10.1186/1471-2407-14-595
- Duffin J. Medical Miracles: Doctors, Saints, and Healing in the Modern World. Oxford: 2008.
- Pukel C. Immunotherapy in the twentieth century: William Coley and Lloyd J. Old. Cancer Therapy Advisor website. Published March 15, 2017.
- Rohdenburg GL. Fluctuations of the growth energy of malignant tumors in man with especial reference to spontaneous reference. Cancer Res. 1918;(3)2:193-225.
- Morton JJ, Morton JH. Cancer as a chronic disease. Ann Surg. 1953;(137):683.
- Everson TC, Cole WH. Spontaneous regression of cancer: preliminary report. Ann Surg. 1956;144(3):366-80.
- Barrett R, Morash B, Roback D, et al. FISH identifies a KAT6A/CREBBP fusion caused by a cryptic insertional t(8;16) in a case of a spontaneously remitting congenital acute myeloid leukemia with normal karyotype. Pediatr Blood Cancer. 2017;64(8). doi: 10.1002/pbc.26450
- D’Arena G, Guariglia R, Pietrantuono G, et al. More on spontaneous regression of chronic lymphocytic leukemia: two new cases and potential role of lamivudine in a further patient with advanced disease and hepatitis B virus infection. Leuk Lymphoma. 2014:55(8):1955-7. doi: 10.3109/10428194.2013.858151
- Udupa K, Philip A, Rajendranath R, Sagar T, Majhi U. Spontaneous regression of primary progressive Hodgkin’s lymphoma in a pediatric patient: a case report and review of literature. Hematol Oncol Stem Cell Ther. 2013;6(3-4):112-6. doi: 10.1016/j.hermonc.2013.06.004
- Takahashi T, Ikejiri F, Takami S, et al. Spontaneous regression of intravascular large b-cell lymphoma and apoptosis of lymphoma cells: a case report. J Clin Exp Hematop. 2015;55(3):151-6. doi: 10.3960/jstrt.55.151
- Ito E, Nakano S, Otsuka M, et al. Spontaneous breast cancer remission: a case report. Int J Surg Case Rep. 2016;25:132-6. doi: 10.1016/j.ijscr.2016.06.017
- Nakamura Y, Noguchi Y, Satoh, E et al. Spontaneous remission of a non-small cell lung cancer possibly caused by anti-NY-ESO-1 immunity. Lung Cancer. 2009:65(1):119-22. doi: 10.1016/j.lungcan.2008.12.020
- Kitai H, Sakakibara-Konishi J, Oizumi S, et al. Spontaneous regression of small cell lung cancer combined with cancer associated retinopathy. Lung Cancer. 2015;87(1):73-6. doi: 10.1016/j.lung ca.2014.10.015
- Balzer BL, Ulbright TM. Spontaneous regression of testicular germ cell tumors: an analysis of 42 cases. Am J Surg Path. 2006;30(7):858-65.
- Lee T, Guo Y, Vij S, Bansal R, Wong NC, Shayegan B. Case: spontaneous regression of post-radical prostatectomy prostate-specific antigen elevation without adjuvant therapy in a patient with lymph node metastasis. Can Urol Assoc J. 2017;11(7):E315-7. http://dx.doi.org/10.5489/cuaj.4324
- Katano A, Takenaka R, Okuma K, Yamashita H, Nakagawa K. Repeated episodes of spontaneous regression/progression of cervical adenocarcinoma after adjuvant chemoradiation therapy: a case report. J Med Case Rep. 2015;9:114.
- Parks AL, McWhirter RM, Evason K, Kelley RK. Cases of spontaneous tumor regression in hepatobiliary cancers: implications for immunotherapy? J Gastrointest Cancer. 2015;46(2):161-5. doi: 10.1007/s12029-015-9690-7
- Chida K, Nakanishi K, Shomura H, et al. Spontaneous regression of transverse colon cancer: a case report. Surg Case Rep. 2017;3:65. doi: 10.1186/s40792-017-0341-z
- Pang C, Sharma D, Sankar T. Spontaneous regression of Merkel cell carcinoma: a case report and review of the literature. Int J Surg Case Rep. 2015;7C104-8. doi: 10.1016/j.ijscr.2014.11.027
- Bonvalot S, Ternes N, Fiore M, et al. Spontaneous regression of primary abdominal wall desmoid tumors: more common than previously thought. Ann Surg Oncol. 2013;20(13);4096-102. doi: 10.1245/s10434-013-3197-x
- Miller CV, Cook IS, Jayaramachandran R, Tyers AG. Spontaneous regression of a conjunctival malignant melanoma. Orbit. 2014;33(2);139-41. doi: 10. 3109/01676830.2013.851708.
- Diede SJ. Spontaneous regression of metastatic cancer: learning from neuroblastoma. Nat Rev Cancer. 2014;14(2):71-2 doi: 10.1038/nrc3656
- Buder T, Deutsch A, Klink B, Voss-Bohme A. Model-based evaluation of spontaneous tumor regression in pilocytic astrocytoma. PLoS Comput Biol. 2015;11(12):e1004662. doi: 10.1371/journal.pcbi.1004662
- Murphy KA, James BR, Guan Y, Torry DS, Wilber A, Griffith TS. Exploiting natural anti-tumor immunity for metastatic renal cell carcinoma. Hum Vaccin Immunother. 2015;11(7):1612–16.
- Kucerova P, Cervinkova M. Spontaneous regression of tumour and the role of microbial infection – possibilities for cancer treatment. Anticancer Drugs. 2016;27(4):269-277.
- Jhawar SR, Thandoni A, Bommareddy PK, et al. Oncolytic viruses-natural and genetically engineered cancer immunotherapies. Front Oncol. 2017;7:202. doi: 10.3389/fonc.2017.00202
- Corrigan PA, Beaulieu C, Patel RB, Lowe DK. Talimogene laherparepvec: an oncolytic virus therapy for melanoma. Ann Pharmacother. 2017:51(6):675-81. doi: 10.1177/1060028017702654
- Lee CH. Engineering bacteria toward tumor targeting for cancer treatment: current state and perspectives. Appl Microbiol Biotechnol. 2012;93(2):517-23. doi: 10. 1007/s00253-011-3695-3
- Howells A, Marelli G, Lemoine NR, Wang Y. Oncolytic viruses-interaction of virus and tumor cells in the battle to eliminate cancer. Front Oncol. 2017;7:195. doi: 10.3389/fonc.2017.00195
- Geng Q, Jiao P, Jin P, Su G, Dong J, Yan B. PD-1/PD-L1 inhibitors for immuno-oncology: from antibodies to small molecules. Curr Pharm Des. 2017 Oct 4. doi: 10.2174/1381612823666171004120152 [Epub ahead of print]
- Wilkins O, Keeler AM, Flotte TR. CAR T-cell therapy: progress and prospects. Hum Gene Ther Methods. 2017;28(2):61-6. doi: 10.1089/hgtb.2016.153
- Schreiber RD, Old LJ, Smyth MJ. Cancer Immunoediting: integrating immunity’s roles in cancer suppression and promotion. Science. 2011;331(6024):1565-70. doi: 10.1126/science.1203486
- Cong Y, Shen G, Wu S, Hao R. Abscopal regression following SABR for non-small-cell-lung cancer: a case report. Cancer Biol Ther. 2017;18(1):1-3. doi: 10.1080/15384047.2016.1264541